Tail gas distillation column is a key component of the cryogenic separation unit in front-end depropanization front-end hydrogenation process. It separates ethylene, ethane, methane and hydrogen for the purpose of reducing ethylene loss, improving ethylene yield, and reducing the cooling load of demethanizer, ethylene refrigeration compressor and propylene refrigeration compressor. Based on the operation analysis of the tail gas distillation column under high load, the factors influencing the operation of tail gas distillation column are discussed under the condition that the system equipment of tail gas distillation column and the cracking conditions remain unchanged. Through operation adjustment and technical transformation, the long-term, full-load and high-quality operation of the system under high load was achieved.