Tube bundle of heat exchanger frequently leaks due to corrosion, leading to the pollution of water or products, affecting heat transfer effect and seriously threatening the normal production. To solve the corrosion leakage problem of the effluent exchanger for the second-stage reactor of gasoline hydrogenation unit in ethylene plant, this paper discusses the reasons for the corrosion leakage of heat exchanger from the aspects of design, operation, maintenance and water treatment, and proposes some corresponding optimization measures.