Compressor unit is an important core component of ethylene plant. During the operation of the compressor unit at SINOPEC Zhongyuan Petrochemical Corp. Ltd., some problems such as the high vibration of ethylene compressor turbine and the failure of self-operated valve in the filter switching process of propylene compressor oil station occurred. An effective solution was put forward to solve the problems affecting the long-term stable operation of the compressors. This paper also introduces the experience in management of the compressors, so as to ensure the long-term operation of the compressor unit and improve the economic benefit of the plant.