This paper systematically introduces the piping design of a 150 kt/a single-chamber cracking furnace. Taking the piping design of a cracking furnace in a domestic ethylene plant as a practical case study, it focuses on the determination of planar layout scheme for the cracking furnace area, the support structure and positioning design of vertical quench heat exchangers, the piping design strategies for cracked gas conveying system and riser/downcomer, as well as the design principles for column spacing in front-furnace pipe racks and the layout schemes for feed pipe valve groups. Through feasibility verification of standardized design for critical equipment selection and core piping system configuration in the cracking furnace, this study proposes standardized layout solutions with engineering practical value.