At present, the newly built ethylene plants in China show an increasingly prominent trend of large-scale development. The design capacity of single-set ethylene plants generally exceeds 1.2 Mt/a, and ultra-large ethylene plants with a capacity of 1.5 Mt/a and above have gradually become the mainstream configuration in the industry. As a core high-energy-consumption equipment of ethylene plants, cracking gas compressor can effectively reduce the carbon emissions of ethylene plants by replacing the traditional steam turbine drive with electric motor drive. Taking the cracking gas compressor of a 1.6 Mt/a ethylene plant as the research object, this paper analyzes the impacts of compressor electrification on equipment and piping layout, and summarizes a complete set of layout design schemes. The research results can provide a sound engineering reference for the electrification renovation of cracking gas compressors in ethylene plants of the same scale, and promote the popularization of electrification and high-quality low-carbon development of the refining and chemical industry.