This paper introduces the short-term shutdown and startup of the 220 kt/a ethylene plant with material at PetroChina Dushanzi Petrochemical Company due to the relocation of control room. By preparing management manuals, special plans and operation cards in advance, the professional departments and operation departments of the Company carried out energy isolation control, ensured the construction manpower and the preparation and delivery of project materials, and strengthened the training and defense of supervisors at all levels. Simulation verification was carried out jointly with the repair company, and practical testing and verification were carried out in local areas with necessary conditions, so as to ensure that the risks of DCS/SIS/ITCC system relocation and commissioning are controllable and to further ensure the scientific nature of the project scheme. Mainly focusing on the relocation of control room, the hidden dangers in the equipment, facilities and instrumentation of production units were eliminated. After nearly 15 days of efforts, the intended target was achieved.