To solve the vibration problem of the silencer and pipeline at the outlet of screw compressor in a chemical company, the gas pulsation and pipeline vibration of the existing exhaust pipe was analyzed, the main causes of the pipeline vibration were identified combined with the measured data of pipeline vibration on site, and some corresponding modification measures were put forward. Some reasonable vibration elimination measures were taken such as replacing the silencer with three-chamber impedance compound silencer, revamping the exhaust pipe, installing pipe supports and reinforcing the thermocouple branches. After modification，the pressure unevenness at each point inside the exhaust pipe can meet the requirements of API 619, and the gas pulsation decreased by 72% on average. The first-order natural frequency of the exhaust pipe system increased from 4.572 Hz to 8.862 Hz, and the high-order natural frequency was ±10% away from the compressor excitation frequency. The maximum vibration of the silencer decreased by 64% to 32 mm/s and the maximum vibration of the outlet pipe decreased by 87.5% to 10 mm/s compared with those before the modification, proving the effectiveness of the modification measures.